View abstract. Yurach, M. T., Davis, B. E., and Cockcroft, D. W. The effect of caffeinated coffee on airway response to methacholine and exhaled nitric oxide. View abstract. Canada residents can call a provincial poison control center. Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion during cycle ergometry. Elliman, N. A., Ash, J., and Green, M. W. Pre-existent expectancy effects in the relationship between caffeine and performance. Ferre, S., Popoli, P., Gimenez-Llort, L., Rimondini, R., Muller, C. E., Stromberg, I., Ogren, S. O., and Fuxe, K. Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease. Stop consuming caffeine-containing products at least 24 hours before a cardiac stress test. View abstract. Research suggests that drinking coffee might reduce the risk for liver cirrhosis. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Csajka, C., Haller, C. A., Benowitz, N. L., and Verotta, D. Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? View abstract. Maia, L. and de Mendonca, A. Ann Intern Med 6-6-2006;144(11):785-791. If you have any questions about storage, ask your pharmacist. 12-9-2008;52(24):2008-2016. Mohiuddin, M., Azam, A. T., Amran, M. S., and Hossain, M. A. 2010;20(2):128-130. JRMS 2010;15(3):127-132. B., Coste, O., Doireau, P., Chauffard, F., French, J., and Lagarde, D. Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel. 2004;44(4):338-347. Br.J Clin Pharmacol 2005;59(3):335-345. 2011;31(5):302-310. Ganio, M. S., Klau, J. F., Lee, E. C., Yeargin, S. W., McDermott, B. P., Buyckx, M., Maresh, C. M., and Armstrong, L. E. Effect of various carbohydrate-electrolyte fluids on cycling performance and maximal voluntary contraction. Rhein LM, Dobson NR, Darnall RA, Corwin MJ, Heeren TC, Poets CF, McEntire BL, Hunt CE;Caffeine Pilot Study Group. Vandenberghe C, St-Pierre V, Courchesne-Loyer A, Hennebelle M, Castellano CA, Cunnane SC. 1998;36(1):112-114. View abstract. View abstract. Whalen, D. J., Silk, J. S., Semel, M., Forbes, E. E., Ryan, N. D., Axelson, D. A., Birmaher, B., and Dahl, R. E. Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controls. Oba, S., Nagata, C., Nakamura, K., Fujii, K., Kawachi, T., Takatsuka, N., and Shimizu, H. Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., and Madsen, J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. "Neonatal apnea" describes a condition in which infants have pauses in breathing that last for at least 15 seconds or that cause a serious drop in heart rate. Schmidt, B., Roberts, R. S., Davis, P., Doyle, L. W., Barrington, K. J., Ohlsson, A., Solimano, A., and Tin, W. Long-term effects of caffeine therapy for apnea of prematurity. View abstract. Fernandez-Duenas, V., Sanchez, S., Planas, E., and Poveda, R. Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. View abstract. Eur.J Epidemiol. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Chest 1990;97(5):1083-1085. Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. View abstract. Potential toxicity of caffeine when used as a dietary supplement for weight loss. Wang, J. H., Luo, J. Y., Dong, L., Gong, J., and Tong, M. Epidemiology of gastroesophageal reflux disease: a general population-based study in Xi'an of Northwest China. If you notice other effects not listed above, contact your doctor or pharmacist. View abstract. View abstract. J Alzheimers.Dis. McNaughton, L. R., Lovell, R. J., Siegler, J., Midgley, A. W., Moore, L., and Bentley, D. J. Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipollini L, Aromatario M. Caffeine-related deaths: manner of deaths and categories of risk. Sung, B. H., Whitsett, T. L., Lovallo, W. R., al'Absi, M., Pincomb, G. A., and Wilson, M. F. Prolonged increase in blood pressure by a single oral dose of caffeine in mildly hypertensive men. J Sports Sci 2010;28(8):833-842. View abstract. Effect of green tea catechins with or without caffeine on anthropometric measures: a systemic review and meta-analysis. Acad.Emerg.Med 2010;17(5):570. View abstract. Weber JG, Klindworth JT, Arnold JJ, et al. 2012 Dec;94(12):1033-43. doi: 10.1002/bdra.23050. Duncan, M. J., Lyons, M., and Hankey, J. View abstract. Indian J Med Res 2010;132:36-41. Ann Neurol. 2014 Oct;53(7):1573-9. doi: 10.1007/s00394-014-0662-7. View abstract. Tassaneeyakul, W., Birkett, D. J., McManus, M. E., Tassaneeyakul, W., Veronese, M. E., Andersson, T., Tukey, R. H., and Miners, J. O. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Scand J Gastroenterol.Suppl 1999;230:35-39. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. View abstract. Fifth ed; Boston, MA: Little Brown, 1992. Po, A. L. and Zhang, W. Y. Analgesic efficacy of ibuprofen alone and in combination with codeine or caffeine in post-surgical pain: a meta-analysis. However, caffeine is also a drug that is used in OTC and prescription medications to treat conditions such as headache, asthma, and attention deficit hyperactivity disorder (ADHD). Caffeine use in sports. Withdrawal is more likely if you have used caffeine for a long time or in high doses. Usman A, Jawaid A. Epidemiology of bronchopulmonary dysplasia. Eur.J Pharmacol. View abstract. MacKenzie, T., Comi, R., Sluss, P., Keisari, R., Manwar, S., Kim, J., Larson, R., and Baron, J. View abstract. A., Lee, S. J., Lee, C. H., and Hong, Y. S. Geographical and climatic dependencies of green tea (Camellia sinensis) metabolites: a (1)H NMR-based metabolomics study. Schechter MD, Timmons GD. View abstract. View abstract. J Clin Invest 1986;77(1):222-227. Stop consuming caffeine-containing products at least 24 hours before a cardiac stress test. Eur.J Pharmacol 7-10-1998;352(2-3):207-214. But caffeine does not seem to prevent this condition from developing in premature infants. However, other research suggests that caffeinated coffee intake is linked to a decreased occurrence of depression in adults. View abstract. This is not a complete list of possible side effects. View abstract. Chin Med J (Engl.) The body breaks down caffeine to get rid of it. Verhoef, P., Pasman, W. J., Van Vliet, T., Urgert, R., and Katan, M. B. Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies. Tell your doctor if your condition persists, worsens, or continues to occur again. Tyas, S. L., Manfreda, J., Strain, L. A., and Montgomery, P. R. Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada. Neurobiol Dis. View abstract. View abstract. Iranpour S, Sabour S. Inverse association between caffeine intake and depressive symptoms in US adults: data from National Health and Nutrition Examination Survey (NHANES) 2005-2006. Checkoway H, Powers K, Smith-Weller T, et al. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. View abstract. Schnackenberg, R. C. Caffeine as a substitute for Schedule II stimulants in hyperkinetic children. Hodgson JM, Puddey IB, Burke V, et al. View abstract. Clin.Neurophysiol. Massey LK, Whiting SJ. To know about the caffeine overdose symptoms, read the article below. J Toxicol Clin Toxicol 1988;26:407-15. WebMD does not provide medical advice, diagnosis or treatment. 2013 Aug 15;120:93-6. doi: 10.1016/j.physbeh.2013.07.002. Forrest WH Jr, Bellville JW, Brown BW Jr. View abstract. Effects of coffee and caffeine anhydrous intake during creatine loading. Caballero, T., Garcia-Ara, C., Pascual, C., Diaz-Pena, J. M., and Ojeda, A. Urticaria induced by caffeine. Yes, a caffeine overdose can really happen. View abstract. View abstract. Fletcher, D. K. and Bishop, N. C. Effect of a high and low dose of caffeine on antigen-stimulated activation of human natural killer cells after prolonged cycling. Qi H, Li S. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Gasior, M., Swiader, M., Przybylko, M., Borowicz, K., Turski, W. A., Kleinrok, Z., and Czuczwar, S. J. Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. Int J Sport Nutr Exerc.Metab 2008;18(2):116-130. View abstract. Müller SA, Rahbari NN, Schmied BM, Büchler MW. Postuma RB, Anang J, Pelletier A, et al. Pol.J Pharmacol 2001;53(6):615-621. View abstract. View abstract. B. View abstract. Meyer, F. P., Canzler, E., Giers, H., and Walther, H. [Time course of inhibition of caffeine elimination in response to the oral depot contraceptive agent Deposiston. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. View abstract. The stimulant effects of caffeine can block the sleep-producing effects of pentobarbital. View abstract. 1,3,7-Trimethyl-1H-purine- 2,6(3H,7H)-dione, 1,3,7-trimethylxanthine, 1,3,7-triméthylxanthine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione, Anhydrous Caffeine, Cafeina, Caféine, Caféine Anhydre, Caféine Benzodate de Sodium, Caffeine Sodium Benzoate, Caffeine Anhydrous, Caffeine Citrate, Caffeinum, Citrate de Caféine, Citrated Caffeine, Methylxanthine, Méthylxanthine, Trimethylxanthine, Triméthylxanthine. Aggarwal, R., Mishra, A., Crochet, P., Sirimanna, P., and Darzi, A. Epub 2013 31. J Gerontol A Biol Sci Med Sci 1999;54:M275-80. 3-22-1984;310(12):743-746. J Strength.Cond.Res 2008;22(2):464-470. Feldman, M. and Barnett, C. Relationships between the acidity and osmolality of popular beverages and reported postprandial heartburn. A., Rowson, M. J., and De Bruin, E. A. 2017 Oct;35(19):1920-27. Sanderink GJ, Bournique B, Stevens J, et al. J.Pain Symptom.Manage. J Headache Pain 2010;11(4):349-354. Taking caffeine along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects. Rees K, Allen D, Lader M. The influences of age and caffeine on psychomotor and cognitive function. J Psychopharmacol. Headache 2009;49(5):638-645. Di, Monda, V, Nicolodi, M., Aloisio, A., Del Bianco, P., Fonzari, M., Grazioli, I., Uslenghi, C., Vecchiet, L., and Sicuteri, F. Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial. On delayed onset muscle soreness with ephedrine seems to work best Dishman, R. 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